Research Paper Volume 12, Issue 3 pp 2142—2155

Baicalin alleviates benign prostate hyperplasia through androgen-dependent apoptosis

Figure 1. Effect of BC on prostatic enlargement by inhibition of 5α-reductase Type II in TP-treated BPH rat model. Animals were injected with TP for 4 weeks with or without Fina and various concentration of BC. (A) Prostate weight to body weight (PW/BW) ratio and (B) prostate weight in each group were assessed. PW/BW ratio was calculated as (average prostate weight of the experimental group/ average body weight of the experimental group) × 1000. (C) DHT serum concentrations were analyzed using ELISA kit. (D) 5α-reductase Type II mRNA expression was showed by qRT-PCR analysis in prostatic tissues. (E) H&E staining analysis was performed using prostatic tissue sections. Original magnification 100x. (F) Based on H&E staining, TETP was measured and represented. All data are shown as the average value of each experimental group and are mean ± SD (n = 8). P value ### = P < 0.001 versus Con group; * = P < 0.05, ** = P <0.01, *** = P < 0.001 versus the BPH group.