Research Paper Volume 12, Issue 3 pp 2261—2274

TYRO3 facilitates cell growth and metastasis via activation of the Wnt/β-catenin signaling pathway in human gastric cancer cells

Figure 1. Relative TYRO3 expression in gastric cancer (GC) tissues and cell lines. (A) The qRT-PCR analysis of TYRO3 mRNA expression in 55 paired specimens of GC tumor tissues versus corresponding normal tissues. (B) Western blot analyses of TYRO3 protein expressions in 55 paired specimens of GC tissues versus matched normal tissues. (C) Representative images of TYRO3 and β-catenin staining in surgical specimens from 110 paired of GC tissues with or without metastasis and adjacent normal tissues. (D) Quantitative evaluation of TYRO3 expression in tumor tissues and matched normal tissues according to staining scores. (E) Kaplan-Meier analysis of overall survival in patients with variable expression of TYRO3. (F) The qRT-PCR analysis of TYRO3 mRNA expression in GC cell lines and normal gastric epithelial GES-1 cells. (G) Western blot analyses of TYRO3 protein expressions in GC cell lines and normal gastric epithelial GES-1 cells. Glyceraldehyde 3-phosphate dehydrogenase was used as a loading control. *P < 0.05.