Figure 3. (A, B) Genetic alteration profiles associated with PDI signature in TCGA and CGGA datasets. Oncoprint depicts the distribution of the top 20 genes with the highest mutation frequency in each glioma group (low PDI signature vs high PDI signature). (C) Functional annotation of PDI gene family with PDI signature, including GO and KEGG. The upper one panel shows the distribution of PDI signature and clinical features, and the lower two panels show the gene set enrichment in different pathways analyzed by GSVA package of R. TCGA database as training set and CGGA database as the validation set.