Figure 7. (A, B) The significantly mutated genes in gliomas were assigned to low and high risk score groups. Here only the top 20 genes with the highest mutation frequency are displayed in figures. (C) The overall CNAs profile in order of increasing risk score. (D–E) GISTIC 2.0 analysis of cases with low and high risk scores revealed chromosomal regions that were significantly deleted (blue) and amplified (red). The green line represents the significance threshold (q value=0·25). TCGA database as training set and CGGA database as the validation set.