Research Paper Volume 12, Issue 3 pp 2347—2372

Protein disulfide isomerases are promising targets for predicting the survival and tumor progression in glioma patients

Figure 9. Prognostic nomogram for predicting the 3-year and 5-year overall survival of glioma patients. The Schoenfeld residual plots were displayed for risk score (A) Grade III (B) Grade IV (C) 1p19q (D) in the prognostic nomogram. The solid line was a smoothing-spline fit to the plot, with the dashed lines representing the 95% confidence interval. (E) Prognostic nomogram for glioma patients was created based on four key characteristics. (F, G) The calibration curve of OS at 3 years (blue) and 5 years (red). The predicted probability of OS is plotted on the x-axis and the observed OS is plotted on the y-axis. (H, I) ROC curves from the nomogram of 3-year and 5-year OS. The mRNA expression patterns of P4HB (J) PDIA4 (K) PDIA5 (L) and TXNDC12 (M) in glioma cell lines (U251, T98G, A172, U343). TCGA database as training set and CGGA database as the validation set.