Research Paper Volume 12, Issue 3 pp 2408—2427

Integrated analysis of DNA methylation and mRNA expression profiles to identify key genes involved in the regrowth of clinically non-functioning pituitary adenoma


Figure 5. SVM regrowth prediction model. Three ROC curves using LOOCV show the comparisons of the AUC for the prediction of regrowth with 6 genes (A), 13 genes (B) and 7 genes (C). The red line shows the prediction model efficiency, and the blue line shows the permutation p-value of AUC was obtained from 1,000 randomization tests for testing the null hypothesis. The 6-gene model shows a better prediction accuracy.