Research Paper Volume 12, Issue 3 pp 2440—2452

HO-1 induced autophagy protects against IL-1 β-mediated apoptosis in human nucleus pulposus cells by inhibiting NF-κB

Figure 8. Schematic diagram shows potential mechanism of action of HO-1. HO-1 promotes autophagy by increasing the formation of the Beclin-1/PI3KC3 complex. HO-1 induced autophagy protects against apoptosis of human NPCs by inhibiting NF-κB.