Research Paper Volume 12, Issue 3 pp 2471—2484

Sepsis induced cognitive impairments by disrupting hippocampal parvalbumin interneuron-mediated inhibitory network via a D4-receptor mechanism

Figure 4. D4 receptor colocalizes in cells positive for PV and was decreased after CLP. (AB) D4 receptor was significantly decreased after CLP. (CD) Most PV interneurons co-express D4 receptor and a large proportion of D4 receptor-expressing neurons in the hippocampus co-express PV. Arrow: coexpress D4 receptor and PV; Arrowhead: express D4 receptor without parvalbumin. (C and E) Decreased PV and D4 expressions were observed after CLP when compared with sham + NS group. *P < 0.05 vs sham group, scale bar = 50 μm.