Research Paper Volume 12, Issue 3 pp 2471—2484

Sepsis induced cognitive impairments by disrupting hippocampal parvalbumin interneuron-mediated inhibitory network via a D4-receptor mechanism

Figure 6. RO-10-5824 treatment reversed CLP–induced cognitive impairment. (AB) CLP did not affect the distance traveled and time spent in center in the open arena. (C) CLP induced significantly decreased freezing time in the contextual fear conditioning, which was prevented by RO-10-5824. (D) There was no difference in the freezing time in the cued test. (E) CLP induced significantly decreased time with the novel object. (F) CLP induced significantly decreased novel object recognition ratio, which was reversed by RO-10-5824. Data are shown as mean ± SD (n = 11), *P < 0.05 vs sham + NS group, #P < 0.05 vs CLP + NS group.