Research Paper Volume 12, Issue 3 pp 2485—2497

Circular RNA hsa_circ_0056836 functions an oncogenic gene in hepatocellular carcinoma through modulating miR-766-3p/FOSL2 axis

Figure 1. Hsa_circ_0056836 was overexpressed in HCC tumor tissues and cell lines. (A) The genomic loci of hsa_circ_0056836. (B) hsa_circ_0056836 expression in HCC tissues was examined by RT-PCR (n = 76). (C) the diagnostic value of hsa_circ_0056836 in HCC was detected by ROC curve (AUC = 0.8742, 95% CI =0.7385-0.9503, P < 0.0001). (D) Kaplan–Meier survival curve of patients in low and high hsa_circ_0056836 expression groups. (E) hsa_circ_0056836 expression levels examined by RT-PCR. (F) Subcellular localization of hsa_circ_0056836 was determined by In situ hybridization assay. *P < 0.05, **P < 0.01, ***P < 0.001 vs control group.