Research Paper Volume 12, Issue 3 pp 2485—2497

Circular RNA hsa_circ_0056836 functions an oncogenic gene in hepatocellular carcinoma through modulating miR-766-3p/FOSL2 axis

Figure 6. Effects of hsa_circ_0056836 or miR-766-3p shown by a tumor xenograft model. SK-HEP-1 cells stably silencing hsa_circ_0056836 or miR-766-3p were inoculated subcutaneously into the BALB/c nude mice. (A) Representative images of xenograft tumors in nude mice. (B) Tumor sizes were calculated in different groups. (C, D) Expression of hsa_circ_0056836 and miR-766-3p in tumors detected by qRT-PCR. (E, F) Expression of FOSL2 in tumors detected by qRT-PCR. (G) Apoptosis was detected by TUNEL assay and immunohistochemistry staining of Ki-67. **P < 0.01, ***P < 0.001 vs. control group, ###P < 0.001 vs sicircRNA group.