Figure 1. Multiple spline regression analyses were used to analyze the association between MHR and HT, (A) symptomatic HT (B) with three knots (at the 10th, 50th, 90th percentiles). Solid line indicates adjusted odds ratios, and dotted line indicates 95% confidence intervals. Reference of MHR was the midpoint (0.57). Odds ratios for HT were adjusted for age, sex, atrial fibrillation, drinking, NIHSS, systolic blood pressure, white blood cell, low-density lipoprotein cholesterol, large infarct size, antiplatelets, thrombolysis, thrombectomy, lipid-lowering agents after admission and TOAST classification, and for symptomatic HT were adjusted for NIHSS and large infarct size. MHR, monocyte to high-density lipoprotein cholesterol ratio; HT, hemorrhagic transformation; NIHSS, National Institutes of Health Stroke Scale score; TOAST, the Trial of ORG 10172 in Acute Stroke Treatment.