Figure 4. Potential synthetic lethal genetic interactions in CCA. (A) Distribution of mutation genes across cancer types based on 26 screened genes. (B) Distribution of mutation gens across individuals for 4 genes with mutation. (C) Distribution of interacted numbers based on validated/predicted synthetic lethal genetic interactions, and several genes with more than 10 interactions are also presented. (D) Interaction networks among synthetic lethal genetic interactions based on 26 genes. Networks of 4 genes with mutations are detailed presented on the right, and the correlations with the 4 genes are also presented. * indicates significant correlations between these interacted genes (FDR < 0.05).