Research Paper Volume 12, Issue 3 pp 2626—2646

Screening and identification of genes associated with cell proliferation in cholangiocarcinoma

Figure 4. Potential synthetic lethal genetic interactions in CCA. (A) Distribution of mutation genes across cancer types based on 26 screened genes. (B) Distribution of mutation gens across individuals for 4 genes with mutation. (C) Distribution of interacted numbers based on validated/predicted synthetic lethal genetic interactions, and several genes with more than 10 interactions are also presented. (D) Interaction networks among synthetic lethal genetic interactions based on 26 genes. Networks of 4 genes with mutations are detailed presented on the right, and the correlations with the 4 genes are also presented. * indicates significant correlations between these interacted genes (FDR < 0.05).