Research Paper Volume 12, Issue 3 pp 2764—2776

Age-specific differential changes on gut microbiota composition in patients with major depressive disorder

Figure 3. 16S rRNA gene sequencing reveals changes to microbial abundances in middle-aged MDD patients. (A) OPLS-DA model showed an obvious difference in microbial abundances between the two groups (HCs, n=44; MDD, (n=45); (B) the relative abundances of Bacteroidetes and Actinobacteria were significantly changed in middle-aged MDD patients (n=45) as compared with middle-aged HCs (n=44).