Research Paper Volume 12, Issue 3 pp 2777—2797

TP53/miR-34a-associated signaling targets SERPINE1 expression in human pancreatic cancer


Figure 1. Changes in protein expression profile in MIA-PaCa-2 cells expressing pLXSN compared to WT-TP53. (A) Protein expression was assayed by RPPA. Proteins indicated in red and green denotes increased and decreased expression, respectively. Genes in red and green indicate tumor promoting and suppressor activities, respectively. (B) Schematic demonstrating cell signaling in MIA-PaCa-2+pLXSN cells promoting cell survival (in red) while significantly inhibiting apoptosis (in green).