Research Paper Volume 12, Issue 3 pp 2777—2797

TP53/miR-34a-associated signaling targets SERPINE1 expression in human pancreatic cancer

Figure 2. Effects of treating MIA-PaCa-2 cells with BBR and NAX060 on cell division, proliferation, survival, migration, and apoptosis. A schematic depicting the effects of BBR and NAX060 on the N-RAS/TP53-associated signaling critical to PDAC development. The model is based on the fact that over-expression of mutated KRAS significantly enhances STAT3, NF-κB signaling which in turn lowers the TP53 expression (highlighted and boxed in dotted purple line). Green bold arrows denote inhibiting effects of BBR/MBBR on the signaling molecule.