Research Paper Volume 12, Issue 3 pp 2825—2839

Immune-related key gene CLDN10 correlates with lymph node metastasis but predicts favorable prognosis in papillary thyroid carcinoma

Figure 3. (A) The ROC curve (a) showed that CLDN10 expression can be used as a biomarker distinguishing PTC from normal thyroid tissues (GSE35570; AUC=0.954 (95%CI=0.899-0.984); Specificity=0.9804, Sensitivity=0.9077). The survival curve (b) showed that PTC patients with high CLDN10 expression levels had a longer overall survival time relative to those with low CLDN10 expression ones (P<0.05). (B) CLDN10 expression in PTC tissues and adjacent normal tissues assayed by IHC (×10). (a) cancer tissue; (b) para-cancer tissue; (c) cancer vs normal, P<0.05. (C) The association of CLDN10 protein expression levels with clinical features based on a tissue chip. (a) LNM, N0 vs N1, P<0.05; (b) Age, <45y vs >=45y, P>0.05; (c) Clinical stage, I+II vs III+IV, P>0.05; (d) T stage, T1+T2 vs T3+T4, P>0.05.