Research Paper Volume 12, Issue 3 pp 2825—2839

Immune-related key gene CLDN10 correlates with lymph node metastasis but predicts favorable prognosis in papillary thyroid carcinoma

Figure 4. (A) Correlation of CLDN10 expression with tumor purity and immune cell infiltration levels in thyroid cancer. CLDN10 expression was negatively correlated with tumor purity (r=-0.133, P<0.05), but positively correlated with B cell (r=0.348, P<0.05), CD8+T cell (r=0.13, P<0.05), CD4+T cell (r=0.351, P<0.05), Macrophage (r=0.181, P<0.05), Neutrophil (r=0.509, P<0.05), and Dendritic cell (r=0.52, P<0.05), respectively. (B) The CLDN10 expression was positively correlated with cell markers of CD8+T cell, Tumor-associated macrophage (TAM), M1 macrophage, and M2 macrophage, respectively.