Research Paper Volume 12, Issue 3 pp 2840—2856

Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2

Figure 5. The effect of uric acid on extending life span depends on its regulation of the reproductive signaling pathway. Life span analysis for (A) glp-1 (e2144) and (B) daf-12 (rh274) mutant worms when treated with 2 mM uric acid versus control (P value by log-rank test). Detailed life span values are listed in Supplementary Table 1. (C and D) The number of daily progeny and the total number of progeny of wild-type N2 worms treated with 2 mM uric acid or vehicle (means ± SD, n ≥ 30, n.s.: no significant difference, Student’s t test).