Figure 4. Characteristics of Somatic Mutations in Breast Cancer Patients with Germline Mutations. (A) Three groups according to germline mutations: Germline-BRCA1/2, Germline-others (non-BRCA) and Others (non-carriers). (B) Somatic mutation positive detection rate among the three groups. (C) The difference of the mutation type distribution among the three groups. (D) The difference of the mutation genes among the three groups. * P<0.05. (E). PIK3CA mutation spectrum in the three groups.