Research Paper Volume 12, Issue 3 pp 2897—2920

Identifying lncRNA–miRNA–mRNA networks to investigate Alzheimer’s disease pathogenesis and therapy strategy

Figure 6. The lncRNA-associated ceRNA networks in APP/PS1 mice. CeRNA networks were constructed based on identified lncRNA–miRNA and miRNA–mRNA interactions. The networks include increased lncRNAs, decreased miRNAs, and increased mRNAs in APP/PS1 mice. (A) Grouping (B) 6yes9no group, (C) 6no9yes group, and (D) 6yes9yes group.