Research Paper Volume 12, Issue 3 pp 2974—2991

Long non-coding RNA TUSC8 inhibits breast cancer growth and metastasis via miR-190b-5p/MYLIP axis

Figure 1. The TUSC8 is significantly down-regulated in breast cancer tissues and predicts better prognosis of breast cancer patients. (A) The down-regulation of TUSC8 expression in breast cancer samples (n=1104) compared with adjacent normal breast tissues (n=113) in TCGA database. (B) The TUSC8 expression levels were significantly down-regulated in multiple breast cancer cell lines compared with normal breast cancer cell line MCF-10A. (C) The survival curves of TUSC8 in breast cancer TCGA and GSE96058 dataset by using the median cut-off method and optimal cut-off method (20th percentage). (D) The expression levels of TUSC8 in different stages of breast cancer patients. The asterisks (*, **) indicate a significant difference (p < 0.05, p < 0.01) respectively. Abbreviations: NPI: Nottingham prognostic index; AOL: Adjuvant! Online; AE: Any event; Nm: Nodal status mixed (contain positive and negative); ERm: Oestrogen receptor status mixed (contain positive and negative).