Research Paper Volume 12, Issue 3 pp 2974—2991

Long non-coding RNA TUSC8 inhibits breast cancer growth and metastasis via miR-190b-5p/MYLIP axis

Figure 2. TUSC8 inhibits breast cancer cell growth, invasion and metastasis. (A) The good over-expression efficiency of TUSC8 in breast cancer cell lines SK-BR-3 and MDA-MB-435. (B) The good knock-down efficiency of TUSC8 in breast cancer cell lines MCF-7 and HCC1937 by using different shRNA subclones. (C) Over-expression of TUSC8 significantly suppressed breast cancer cell growth by cell proliferation assay. (D) Knock-down of TUSC8 drastically promoted breast cancer cell growth by cell proliferation assay. (E) Over-expression of TUSC8 reduced the cell invasive capacities in breast cancer cell lines SK-BR-3 and MDA-MB-435 by transwell invasion assay. (F) Knock-down of TUSC8 enhanced the cell invasive capacities in breast cancer cell lines MCF-7 and HCC1937 by transwell invasion assay. The asterisks (*, **) indicate a significant difference (p < 0.05, p < 0.01) respectively.