Figure 1. Ligustilide improves aging-induced cognitive dysfunction in SAMP8 mice. (A) The chemical structure of ligustilide. (B) Escape latency from five consecutive days of tests. (C) The swimming paths of each respective group on the sixth day. (D) Crossing times of the target platform in the probe trial. (E) Time spent in the target quadrant in the probe trial. (F) The swimming speed in the probe trial. Ligustilide 10 (10 mg/kg/d); Ligustilide 20 (20 mg/kg/d). Data represent mean ± SD (n = 20 per group). #p < 0.05, ##p < 0.01, ###p < 0.001 versus SAMR1; *p < 0.05, **p < 0.01, ***p < 0.001 versus SAMP8.