Research Paper Volume 12, Issue 3 pp 2992—3009

EGF released from human placental mesenchymal stem cells improves premature ovarian insufficiency via NRF2/HO-1 activation

Figure 1. hPMSCs improved the function of a POI mouse model. (A) The number of primordial follicles recovered to normal levels four weeks after hPMSC transplantation. (B) hPMSC transplantation restored the primary follicle numbers. (C) hPMSC elevated the number of secondary follicles to the WT group level (D) hPMSC transplantation elevated the number of antral follicles to the WT group level. (E) ELISA results indicated that hPMSC transplantation increased the levels of E2. (F) hPMSC transplantation improved the levels of AMH. (G) hPMSC transplantation decreased the levels of FSH to the WT group level. All experiments were carried out three times; error bars indicate the SD; *** p < 0.001 (compared with the POI group). POI = premature ovarian insufficiency, hPMSC = human placental mesenchymal stem cell.