Research Paper Volume 12, Issue 3 pp 2992—3009

EGF released from human placental mesenchymal stem cells improves premature ovarian insufficiency via NRF2/HO-1 activation

Figure 3. EGF derived from hPMSCs was observed at higher levels than other growth factors. (A) Antibody microarray analysis of growth factor secretion from the hPMSC and control groups (293T cell line). Four growth factors were selected in accordance with standard criteria: the fold change was greater than or equal to sixteen, and there was statistical significance (p< 0.01). (B) EGF derived from hPMSCs was secreted at higher levels than other growth factors. (C) EGF was highly expressed in the POI mouse model after hPMSC transplantation. All experiments were carried out three times. hPMSC = human placental mesenchymal stem cell.