Research Paper Volume 12, Issue 3 pp 3025—3041

Obg-like ATPase 1 (OLA1) overexpression predicts poor prognosis and promotes tumor progression by regulating P21/CDK2 in hepatocellular carcinoma

Figure 4. Downregulation of OLA1 arrests the cell cycle in HCC cells. (A) GSEA using TCGA datasets suggested that OLA1 is related to the cell cycle in HCC. (B) Correlation analysis showed that OLA1 is strongly related to CDK1, CDK2, CDK4, CCNB1 and CCNB2. (C and D) Depletion of OLA1 triggered G0/G1 blockade in LM3 and MHCC-97H cells. (E) Western blot analysis suggested that knockdown of OLA1 downregulated CDK1, CDK2, CDK4, CCNB1 and CCNB2. All *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.