Research Paper Volume 12, Issue 3 pp 3025—3041

Obg-like ATPase 1 (OLA1) overexpression predicts poor prognosis and promotes tumor progression by regulating P21/CDK2 in hepatocellular carcinoma


Figure 7. OLA1 correlates with CDK2 in HCC. (A) High expression of CDK2 was associated with poor survival outcomes of HCC. (B) CDK2 expression level is highly relevant to OLA1 expression. (C) Our HCC clinical samples also demonstrated a high correlation of OLA1 and CDK2. (D) Representative images of OLA1 and CDK2 co-expression staining in HCC specimens. (E) Schematic of the above-mentioned findings. OLA1 influences cell cycle, apoptosis and progression in LM3 and MHCC-97H cells by the interaction with P21 and upregulation of CDK2.