Research Paper Volume 12, Issue 3 pp 3042—3052

Entorhinal cortex-based metabolic profiling of chronic restraint stress mice model of depression

Figure 5. Summarizing schematic of identified molecular alterations in EC after CRS process. Alterations in metabolites and related molecules in monoaminergic and glutamatergic pathways in the EC of CRS mice (red arrow) were presented. Targeted metabolomics was used to measure altered metabolites. Molecular approaches were used to verify changes of key enzymes and transporters in monoaminergic and glutamatergic pathways.