Research Paper Volume 12, Issue 5 pp 4093—4110

Exosomal miR-19a from adipose-derived stem cells suppresses differentiation of corneal keratocytes into myofibroblasts

Figure 7. Putative mechanism by which ADSCs-Exo-miR-19a suppress the FBS-induced differentiation of rabbit corneal keratocytes into myofibroblasts. ADSCs-Exo-miR-19a suppresses FBS-induced differentiation of keratocytes into myofibroblasts by inhibiting HIPK2 expression. Reduced HIPK2 levels suppress the TGF-β/Smad3 and p53 signaling pathways, and reduce the expression of pro-fibrotic markers and ECM components. Overall, these events decrease cell viability and ECM degradation.