Volume 12, Issue 5

15 March, 2020
pp 4045—4681

About the Cover

The cover features Figure 3 "Top 15 significant GO classes identified in the different cell types combining the results for the seven brain regions analyzed“ from Piras et al.

Request Issue Reprint

Table of Contents

Editorials

PoEMs edit breast cancer outcome

Pawel Bieniasz-Krzywiec, Massimiliano Mazzone,

https://doi.org/10.18632/aging.102870 pp 4045—4047

PDF How to Cite Request Reprint

Fasting for stem cell rejuvenation

Cristina González-Estévez, Ignacio Flores,

https://doi.org/10.18632/aging.102912 pp 4048—4049

PDF How to Cite Request Reprint

Transient and late-life rapamycin for healthspan extension

Ellen K. Quarles, Peter S. Rabinovitch,

https://doi.org/10.18632/aging.102947 pp 4050—4051

PDF How to Cite Request Reprint

Priority Research Paper

Survey of senescent cell markers with age in human tissues

M. Laura Idda, Waverly G. McClusky, Valeria Lodde, Rachel Munk, Kotb Abdelmohsen, Martina Rossi, Myriam Gorospe,

https://doi.org/10.18632/aging.102903 pp 4052—4066

View Abstract PDF Full-Text How to Cite Request Reprint

Research Papers

HIF-1α/microRNA-128-3p axis protects hippocampal neurons from apoptosis via the Axin1-mediated Wnt/β-catenin signaling pathway in Parkinson’s disease models

Guangping Zhang, Luzhu Chen, Jing Liu, Yan Jin, Zaihong Lin, Shu Du, Zenghui Fu, Tuantuan Chen, Yinghui Qin, Fenghu Sui, Yan Jiang,

https://doi.org/10.18632/aging.102636 pp 4067—4081

View Abstract PDF Full-Text How to Cite Request Reprint

Obstructive sleep apnea syndrome and causal relationship with female breast cancer: a mendelian randomization study

Xiao-Ling Gao, Zhi-Mei Jia, Fang-Fang Zhao, Dong-Dong An, Bei Wang, Er-Jing Cheng, Yan Chen, Jian-Nan Gong, Dai Liu, Ya-Qiong Huang, Jiao-Jiao Yang, Shu-Juan Wang,

https://doi.org/10.18632/aging.102725 pp 4082—4092

View Abstract PDF Full-Text How to Cite Request Reprint

Exosomal miR-19a from adipose-derived stem cells suppresses differentiation of corneal keratocytes into myofibroblasts

Ting Shen, Qingqing Zheng, Hongbo Luo, Xin Li, Zhuo Chen, Zeyu Song, Guanfang Zhou, Chaoyang Hong,

https://doi.org/10.18632/aging.102802 pp 4093—4110

View Abstract PDF Full-Text How to Cite Request Reprint

Long noncoding RNA LINC00461 induced osteoarthritis progression by inhibiting miR-30a-5p

Yuanmin Zhang, Longfei Ma, Chengqun Wang, Lina Wang, Yanxia Guo, Guodong Wang,

https://doi.org/10.18632/aging.102839 pp 4111—4123

View Abstract PDF Full-Text How to Cite Request Reprint

ESHRD: deconvolution of brain homogenate RNA expression data to identify cell-type-specific alterations in Alzheimer’s disease

Ignazio S. Piras, Christiane Bleul, Joshua S. Talboom, Matthew D. De Both, Isabelle Schrauwen, Glenda Halliday, Amanda J. Myers, Geidy E. Serrano, Thomas G. Beach, Matthew J. Huentelman,

https://doi.org/10.18632/aging.102840 pp 4124—4162

View Abstract PDF Full-Text How to Cite Request Reprint

Reduced Ca²⁺ spark activity contributes to detrusor overactivity of rats with partial bladder outlet obstruction

Ji Zheng, Hao Zhou, Mengjun Yang, Siji Song, Qiang Dai, Guangju Ji, Zhansong Zhou,

https://doi.org/10.18632/aging.102855 pp 4163—4177

View Abstract PDF Full-Text How to Cite Request Reprint

SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity

Xiaojun Feng, Yanan Wang, Wenxu Chen, Suowen Xu, Lingli Li, Yadi Geng, Aizong Shen, Hui Gao, Lei Zhang, Sheng Liu,

https://doi.org/10.18632/aging.102862 pp 4178—4192

View Abstract PDF Full-Text How to Cite Request Reprint

Levels of serum S100B are associated with cognitive dysfunction in patients with type 2 diabetes

Huan Yu, Hui Li, Xiaoqian Liu, Xiaoli Du, Binbin Deng,

https://doi.org/10.18632/aging.102873 pp 4193—4203

View Abstract PDF Full-Text How to Cite Request Reprint

Comprehensive characterization of endometrial competing endogenous RNA network in infertile women of childbearing age

Meihua Zhang, Junxia Li, Shuyin Duan, Zhenya Fang, Jiaqi Tian, Haoyu Yin, Qingfeng Zhai, Xietong Wang, Lin Zhang,

https://doi.org/10.18632/aging.102874 pp 4204—4221

View Abstract PDF Full-Text How to Cite Request Reprint

Identification of frailty-associated genes by coordination analysis of gene expression

Youwen Zhang, Ioulia Chatzistamou, Hippokratis Kiaris,

https://doi.org/10.18632/aging.102875 pp 4222—4229

View Abstract PDF Full-Text How to Cite Request Reprint

Development, validation and clinical impact of a prediction model for 6-month mortality in older cancer patients: the GRADE

Eurydice Angeli, Kader Chouahnia, Florence Canoui-Poitrine, Boris Duchemann, Thomas Aparicio, Elena Paillaud, Laurent Zelek, Guilhem Bousquet, Frédéric Pamoukdjian,

https://doi.org/10.18632/aging.102876 pp 4230—4246

View Abstract PDF Full-Text How to Cite Request Reprint

Downregulation of lung miR-203a-3p expression by high-altitude hypoxia enhances VEGF/Notch signaling

Wei Cai, Sanli Liu, Ziquan Liu, Shike Hou, Qi Lv, Huanhuan Cui, Xue Wang, Yuxin Zhang, Haojun Fan, Hui Ding,

https://doi.org/10.18632/aging.102878 pp 4247—4267

View Abstract PDF Full-Text How to Cite Request Reprint

GAA compound heterozygous mutations associated with autophagic impairment cause cerebral infarction in Pompe disease

Xiaodong Jia, Libin Shao, Chengcheng Liu, Tuanzhi Chen, Ling Peng, Yinguang Cao, Chuanchen Zhang, Xiafeng Yang, Guifeng Zhang, Jianlu Gao, Guangyi Fan, Mingliang Gu, Hongli Du, Zhangyong Xia,

https://doi.org/10.18632/aging.102879 pp 4268—4282

View Abstract PDF Full-Text How to Cite Request Reprint

Secondary injury to distal regions after intracerebral hemorrhage influence neurological functional outcome

Kangping Song, Xiaojie Liu, Qiuyue Zheng, Lingling Zhang, Hongying Zhang, Hailong Yu, Yan Zhu, Li-An Huang, Yingzhu Chen,

https://doi.org/10.18632/aging.102880 pp 4283—4298

View Abstract PDF Full-Text How to Cite Request Reprint

Transient ischemia-reperfusion induces cortical hyperactivity and AMPAR trafficking in the somatosensory cortex

Yuanyuan Li, Ran Ding, Feifei Wang, Cuiping Guo, Aili Liu, Liangpeng Wei, Shiyang Yuan, Feng Chen, Shaowei Hou, Zengguang Ma, Yan Zhang, Robert H. Cudmore, Xiaochuan Wang, Hui Shen,

https://doi.org/10.18632/aging.102881 pp 4299—4321

View Abstract PDF Full-Text How to Cite Request Reprint

Sirt1 antisense long non-coding RNA attenuates pulmonary fibrosis through sirt1-mediated epithelial-mesenchymal transition

Weibin Qian, Xinrui Cai, Qiuhai Qian,

https://doi.org/10.18632/aging.102882 pp 4322—4336

View Abstract PDF Full-Text How to Cite Request Reprint

Surgical blood loss during holmium laser enucleation of the prostate (HoLEP) is not affected by short-term pretreatment with dutasteride: a double-blind placebo-controlled trial on prostate vascularity

Gian Maria Busetto, Francesco Del Giudice, Martina Maggi, Gabriele Antonini, Daniele D’Agostino, Daniele Romagnoli, Alessandro Del Rosso, Marco Giampaoli, Paolo Corsi, Katie Palmer, Matteo Ferro, Giuseppe Lucarelli, Daniela Terracciano, Ottavio De Cobelli, Alessandro Sciarra, Ettore De Berardinis, Angelo Porreca,

https://doi.org/10.18632/aging.102883 pp 4337—4347

View Abstract PDF Full-Text How to Cite Request Reprint

Brain hemodynamic changes in amnestic mild cognitive impairment measured by pulsed arterial spin labeling

Xiangbin Wang, Ding Ding, Qianhua Zhao, Xiaoniu Liang, Ling Peng, Xiaohu Zhao, Qian Xi, Zhang Min, Wei Wang, Xiaowen Xu, Qihao Guo, Pei-Jun Wang,

https://doi.org/10.18632/aging.102888 pp 4348—4356

View Abstract PDF Full-Text How to Cite Request Reprint

Elevated systemic inflammatory responses, factors associated with physical and mental quality of life, and prognosis of hepatocellular carcinoma

Yang Deng, Jian Zhu, Ziyi Liu, Maosheng Huang, David W. Chang, Jian Gu,

https://doi.org/10.18632/aging.102889 pp 4357—4370

View Abstract PDF Full-Text How to Cite Request Reprint

Vitamin D levels are prognostic factors for connective tissue disease associated interstitial lung disease (CTD-ILD)

Yujuan Gao, Qi Zhao, Xiaohua Qiu, Yi Zhuang, Min Yu, Jinghong Dai, Hourong Cai, Xin Yan,

https://doi.org/10.18632/aging.102890 pp 4371—4378

View Abstract PDF Full-Text How to Cite Request Reprint

Genetic variants in RET, ARHGEF3 and CTNNAL1, and relevant interaction networks, contribute to the risk of Hirschsprung disease

Yang Wang, Qian Jiang, Hao Cai, Ze Xu, Wenjie Wu, Beilin Gu, Long Li, Wei Cai,

https://doi.org/10.18632/aging.102891 pp 4379—4393

View Abstract PDF Full-Text How to Cite Request Reprint

DNA methylation clocks as a predictor for ageing and age estimation in naked mole-rats, Heterocephalus glaber

Robert Lowe, Amy F. Danson, Vardhman K. Rakyan, Selin Yildizoglu, Frédéric Saldmann, Melanie Viltard, Gérard Friedlander, Chris G. Faulkes,

https://doi.org/10.18632/aging.102892 pp 4394—4406

View Abstract PDF Full-Text How to Cite Request Reprint

Telomere shortening reflecting physical aging is associated with cognitive decline and dementia conversion in mild cognitive impairment due to Alzheimer’s disease

Seong-Ho Koh, Seong Hye Choi, Jee Hyang Jeong, Jae-Won Jang, Kyung Won Park, Eun-Joo Kim, Hee Jin Kim, Jin Yong Hong, Soo Jin Yoon, Bora Yoon, Ju-Hee Kang, Jong-Min Lee, Hyun-Hee Park, Jungsoon Ha, Young Ju Suh, Suyeon Kang,

https://doi.org/10.18632/aging.102893 pp 4407—4423

View Abstract PDF Full-Text How to Cite Request Reprint

Discovery and validation of the prognostic value of the lncRNAs encoding snoRNAs in patients with clear cell renal cell carcinoma

Wuping Yang, Kenan Zhang, Lei Li, Kaifang Ma, Baoan Hong, Yanqing Gong, Kan Gong,

https://doi.org/10.18632/aging.102894 pp 4424—4444

View Abstract PDF Full-Text How to Cite Request Reprint

Distribution patterns of microsatellites and development of its marker in different genomic regions of forest musk deer genome based on high throughput sequencing

Wen-Hua Qi, Ting Lu, Cheng-Li Zheng, Xue-Mei Jiang, Hang Jie, Xiu-Yue Zhang, Bi-Song Yue, Gui-Jun Zhao,

https://doi.org/10.18632/aging.102895 pp 4445—4462

View Abstract PDF Full-Text How to Cite Request Reprint

Role of eotaxin-1/CCL11 in sepsis-induced myocardial injury in elderly patients

Ying Li, Youguang Zhao, Chenming Qiu, Yuanrui Yang, Guihua Liao, Xi Wu, Xiaowan Zhang, Qian Zhang, Ru Zhang, Zhang Wang,

https://doi.org/10.18632/aging.102896 pp 4463—4473

View Abstract PDF Full-Text How to Cite Request Reprint

Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction

Ting Xin, Chengzhi Lu,

https://doi.org/10.18632/aging.102899 pp 4474—4488

View Abstract PDF Full-Text How to Cite Request Reprint

Methionine abrogates the renoprotective effect of a low-protein diet against diabetic kidney disease in obese rats with type 2 diabetes

Munehiro Kitada, Yoshio Ogura, Itaru Monno, Jing Xu, Daisuke Koya,

https://doi.org/10.18632/aging.102902 pp 4489—4505

View Abstract PDF Full-Text How to Cite Request Reprint

LncRNA GUSBP5-AS promotes EPC migration and angiogenesis and deep vein thrombosis resolution by regulating FGF2 and MMP2/9 through the miR-223-3p/FOXO1/Akt pathway

Li-Li Sun, Feng-Rui Lei, Xu-Dong Jiang, Xiao-Long Du, Lun Xiao, Wen-Dong Li, Xiao-Qiang Li,

https://doi.org/10.18632/aging.102904 pp 4506—4526

View Abstract PDF Full-Text How to Cite Request Reprint

LncRNA-LALR1 upregulates small nucleolar RNA SNORD72 to promote growth and invasion of hepatocellular carcinoma

Lin-Hong Mao, Si-Yuan Chen, Xiao-Qin Li, Feng Xu, Jing Lei, Qing-Liang Wang, Li-Yang Luo, Hai-Yan Cao, Xin Ge, Tao Ran, Xue Li, Min Zou, Zhi-Hang Zhou, Xiao-Ling Wu, Song He,

https://doi.org/10.18632/aging.102907 pp 4527—4546

View Abstract PDF Full-Text How to Cite Request Reprint

ARV-825-induced BRD4 protein degradation as a therapy for thyroid carcinoma

Ling He, Chen Chen, Guoyu Gao, Kun Xu, Zhaoqun Ma,

https://doi.org/10.18632/aging.102910 pp 4547—4557

View Abstract PDF Full-Text How to Cite Request Reprint

Long non-coding RNA RHPN1-AS1 promotes tumorigenesis and metastasis of ovarian cancer by acting as a ceRNA against miR-596 and upregulating LETM1

Junrong Wang, Weimin Ding, Yingke Xu, Enfu Tao, Miaojun Mo, Wei Xu, Xu Cai, Xiaomin Chen, Junhui Yuan, Xiuying Wu,

https://doi.org/10.18632/aging.102911 pp 4558—4572

View Abstract PDF Full-Text How to Cite Request Reprint

APEX1 is a novel diagnostic and prognostic biomarker for hepatocellular carcinoma

Lei Cao, Hongwei Cheng, Qiuxia Jiang, Hui Li, Zhixian Wu,

https://doi.org/10.18632/aging.102913 pp 4573—4591

View Abstract PDF Full-Text How to Cite Request Reprint

Leisure-time physical activity volume, intensity, and duration from mid- to late-life in U.S. subpopulations by race and sex. The Atherosclerosis Risk In Communities (ARIC) Study

Dmitry Kats, Kelly R. Evenson, Donglin Zeng, Christy L. Avery, Priya Palta, Stephen B. Kritchevsky, Gerardo Heiss,

https://doi.org/10.18632/aging.102916 pp 4592—4602

View Abstract PDF Full-Text How to Cite Request Reprint

The prognostic value of tumor mutational burden and immune cell infiltration in esophageal cancer patients with or without radiotherapy

Cheng Yuan, Liyang Xiang, Kuo Cao, Jianguo Zhang, Yuan Luo, Wenjie Sun, Nannan Zhang, Jiangbo Ren, Junhong Zhang, Yan Gong, Conghua Xie,

https://doi.org/10.18632/aging.102917 pp 4603—4616

View Abstract PDF Full-Text How to Cite Request Reprint

Alterations of hand sensorimotor function and cortical motor representations over the adult lifespan

Melina Hehl, Stephan P. Swinnen, Koen Cuypers,

https://doi.org/10.18632/aging.102925 pp 4617—4640

View Abstract PDF Full-Text How to Cite Request Reprint

Effects of the probiotic formulation SLAB51 in in vitro and in vivo Parkinson’s disease models

Vanessa Castelli, Michele d’Angelo, Francesca Lombardi, Margherita Alfonsetti, Andrea Antonosante, Mariano Catanesi, Elisabetta Benedetti, Paola Palumbo, Maria Grazia Cifone, Antonio Giordano, Giovambattista Desideri, Annamaria Cimini,

https://doi.org/10.18632/aging.102927 pp 4641—4659

View Abstract PDF Full-Text How to Cite Request Reprint

Review

Adiponectin in renal fibrosis

Huan Jing, Simin Tang, Sen Lin, Meijuan Liao, Hongtao Chen, Youling Fan, Jun Zhou,

https://doi.org/10.18632/aging.102811 pp 4660—4672

View Abstract PDF Full-Text How to Cite Request Reprint

Research Perspective

The flip side of sirtuins: the emerging roles of protein acetyltransferases in aging

Prabakaran Nagarajan, Mark R. Parthun,

https://doi.org/10.18632/aging.102949 pp 4673—4677

View Abstract PDF Full-Text How to Cite Request Reprint

Corrections

Correction for: ciRs-6 upregulates March1 to suppress bladder cancer growth by sponging miR-653

Yinjie Su, Weilian Feng, Guanglei Zhong, Yiyao Ya, Zehu Du, Juanyi Shi, Luping Chen, Wen Dong, Tianxin Lin,

https://doi.org/10.18632/aging.102885 pp 4678—4679

PDF Full-Text How to Cite Request Reprint

Correction for: A novel rhamnoside derivative PL402 up-regulates matrix metalloproteinase 3/9 to promote Aβ degradation and alleviates Alzheimer’s-like pathology

Tingting Hu, Yue Zhou, Jing Lu, Peng Xia, Yue Chen, Xin Cao, Gang Pei,

https://doi.org/10.18632/aging.102898 pp 4680—4681

PDF Full-Text How to Cite Request Reprint