Research Paper Volume 12, Issue 4 pp 3298—3311

Berberine promotes XIAP-mediated cells apoptosis by upregulation of miR-24-3p in acute lymphoblastic leukemia

Figure 7. Inhibition of XIAP augments the effects of BBR on leukemia phenotype in xenograft mice. (A) Kaplan-Meier survival curves showing the mortality of the mice. (B) Donor-derived ALL cells were analyzed by flow cytometry. (C) Liver sections stained with H&E. (D) The levels of alanine aminotransferase (ALT) and (E) aspartate aminotransferase (AST) in serum were measured. The number of (F) white blood cells (WBC) and (G) red blood cells (RBC) in blood. (H) Serum levels of haemoglobin. Results are expressed as mean ± SD. *p<0.05, **p<0.01, ***p<0.001, compared to the Control or indicated group.