Research Paper Volume 12, Issue 4 pp 3298—3311

Berberine promotes XIAP-mediated cells apoptosis by upregulation of miR-24-3p in acute lymphoblastic leukemia

Figure 8. Expression and correlations of XIAP, PIM-2 and miR-24-3p in ALL samples. The relative expressions of (A) miR-24-3p, (B) PIM-2 and (C) XIAP in the bone marrow of ALL patients (n=39) or normal control (n=3) were detected by qRT-PCR. (D, E) Representative western blot and quantification analysis of PIM-2 and XIAP in ALL and normal samples. (FH) Correlation analysis was performed between miR-24-3p, PIM-2 and XIAP in ALL patients. (I) The signaling pathway of BBR induced ALL cells apoptosis. Results are expressed as mean ± SD, **p<0.01, ***p<0.001, compared to Normal group.