Research Paper Volume 12, Issue 4 pp 3388—3406

Cell-to-cell lactate shuttle operates in heart and is important in age-related heart failure

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Figure 4. Co-culturing-induced changes in visibility of PGAM2 C-terminus, immunostaining intensity of TIGAR, and ROS and lactate production. PGAM2 is presented in white, nuclei are blue. White arrow point to cardiomyocytes. Bar = 10 μm. Lactate production is presented as pmol of lactate per cell per 48 h. Error bars represent standard deviation from three measurements. RFU – relative fluorescence units.