Research Paper Volume 12, Issue 4 pp 3431—3450

Development and validation of a prognostic classifier based on HIF-1 signaling for hepatocellular carcinoma

Figure 4. Construction of integrated risk score based on HIF-1 related genes in the derivation cohort. SLC2A1, ENO1, LDHA, ALDOA, GAPDH, HK2, PKM, PGK1, HIF1A, PFKFB3, PDK1 were significantly correlated with clinical prognosis in univariate Cox regression model (A). The risk score system was constructed using the LASSO Cox regression model (BC). PCA and t-SNE analysis revealed an effective clustering ability of four-gene based risk score (DE).