Research Paper Volume 12, Issue 4 pp 3451—3472

Existence of intratumoral tertiary lymphoid structures is associated with immune cells infiltration and predicts better prognosis in early-stage hepatocellular carcinoma

Figure 2. Clinical relevance of TLS in training cohort. (A) Kaplan–Meier curves showing no significant correlation between the occurrence of TLS and OS (P=0.088); (B) Kaplan–Meier curves showing patients with TLS+ had better RFS (P=0.014); (C and D) Kaplan–Meier curves showing patients with TLS+ had better early RFS (P=0.004) and comparable late RFS (P=0.308); (E and F) Kaplan–Meier curves showing patients with lymphoid follicles had better early RFS (P=0.045) and comparable late RFS (P=0.599) relative to those with lymphoid aggregates; (G) Multivariate analyses for OS; (H) Multivariate analyses showed that TLS was an independent predictor of RFS. TLS, tertiary lymphoid structures; OS, overall survival; RFS, recurrence-free survival.