Research Paper Volume 12, Issue 4 pp 3473—3485

Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism


Figure 5. Principal Components Analysis of transcriptome (A), positive metabolome (B), and negative metabolome (C). Female GHRH-KO- green. Female WT- orange. Male GHRH-KO- blue. Male WT- purple. PC3 and PC2 are associated with sex (P=0.0034) and genotype (P=0.0004) respectively in the transcriptome. PC2 was associated with sex in the positive metabolome (P=0.042), and PC3 was associated with sex in the negative metabolome (P=0.017). Genotype was not significantly associated with any of the PCs shown for either metabolomic dataset.