Research Paper Volume 12, Issue 4 pp 3516—3557

Adaptive selection in the evolution of programmed cell death-1 and its ligands in vertebrates

Figure 9. Adaptive branch-site REL test for episodic diversifying selection in PD1, PD-L1 and PD-L2 genes. The phylogenetic tree scaled on the expected number of substitutions/nucleotides. The hue of each color indicates the strength of selection, with primary red corresponding to ω > 5, primary blue to ω = 0 and grey to ω=1. The width of each color component represents the proportion of sites in the corresponding class. Thicker branches have been classified as undergoing episodic diversifying selection by the sequential likelihood ratio test at corrected ≤0.05.