Research Paper Volume 12, Issue 4 pp 3647—3661

The lncRNA ENSG00000254041.1 promotes cell invasiveness and associates with poor prognosis of pancreatic ductal adenocarcinoma

Figure 3. ENSG00000254041.1 promotes cell cycle and cell proliferation in PC cells. (A) Knockdown of the ENSG00000254041.1 expression decreased the percentage of S-phase and increased G0/G1 phase cell in both of SW1990 and BxPC-3 cells, while overexpression of ENSG00000254041.1 in Panc-1 cells resulted in the opposite effects. (B) Downregulation of ENSG00000254041.1 inhibited proliferation of SW1990 and BxPC-3, while overexpression of ENSG00000254041.1 promoted Panc-1 cells proliferation. Three samples in each group. *p < 0.05, **p < 0.01, ***p < 0.001 compared with si-NC or vector.