Research Paper Volume 12, Issue 4 pp 3647—3661

The lncRNA ENSG00000254041.1 promotes cell invasiveness and associates with poor prognosis of pancreatic ductal adenocarcinoma

Figure 4. ENSG00000254041.1 drives Epithelial-Mesenchymal Transition (EMT). (A) GSEA analysis revealed that ENSG00000254041.1 expression associated with the EMT pathway. (B) Decreased expression of ENSG00000254041.1 in SW1990 and BxPC-3 cells significantly reduced their invasive capacity, while overexpression of ENSG00000254041.1 promoted Panc-1 cells invasion, as measured by a transwell assay. (C) Western blot analysis confirmed that a set of EMT-related proteins was affected by ENSG00000254041.1. Three samples in each group. **p < 0.01, ***p < 0.001 compared with si-NC or vector.