Research Paper Volume 12, Issue 4 pp 3682—3693

Exosomes isolated from the plasma of remote ischemic conditioning rats improved cardiac function and angiogenesis after myocardial infarction through targeting Hsp70

Figure 3. Exosomes from RIC rats significantly promoted cardiac remodeling and angiogenesis after myocardial infarction. (A) Histopathological analysis of heart tissues by HE and Masson (scale bar= 100 μm); (B) Investigation of angiogenesis after RIC exosomes treatment by vWf IHC staining (scale bar= 100 μm); (C) RIC exosomes treatment significantly decreased the infarction ratio; (D) RIC treatment significantly elevated left ventricular ejection fraction; (E) RIC treatment significantly promoted left ventricular fractional shortening. Data were shown as the mean ± SD (n = 3/each group), * P<0.05 compared with respective time point in the control group, # P<0.05 compared with 7 days’ time point in the group RIC exosomes.