Research Paper Volume 12, Issue 4 pp 3682—3693

Exosomes isolated from the plasma of remote ischemic conditioning rats improved cardiac function and angiogenesis after myocardial infarction through targeting Hsp70

Figure 4. Exosomes from RIC markedly improved the cell viability and angiogenesis through promoting Hsp70. (A) RIC exosomes remarkably elevated the expression of Hsp70; (B) RIC exosomes significantly accelerated cell proliferation; (C) RIC exosomes remarkably increased the ratio of cell in G1 stage; (D) RIC exosomes significantly inhibited cell apoptosis; (E) RIC exosomes remarkably promoted cell migration (scale bar= 500 μm); (F) RIC exosomes significantly increased tube formation (scale bar= 500 μm). * P<0.05 compared with the control group. # P<0.05 compared with group si-Hsp70+ RIC exosomes.