Research Paper Volume 12, Issue 4 pp 3682—3693

Exosomes isolated from the plasma of remote ischemic conditioning rats improved cardiac function and angiogenesis after myocardial infarction through targeting Hsp70

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Figure 4. Exosomes from RIC markedly improved the cell viability and angiogenesis through promoting Hsp70. (A) RIC exosomes remarkably elevated the expression of Hsp70; (B) RIC exosomes significantly accelerated cell proliferation; (C) RIC exosomes remarkably increased the ratio of cell in G1 stage; (D) RIC exosomes significantly inhibited cell apoptosis; (E) RIC exosomes remarkably promoted cell migration (scale bar= 500 μm); (F) RIC exosomes significantly increased tube formation (scale bar= 500 μm). * P<0.05 compared with the control group. # P<0.05 compared with group si-Hsp70+ RIC exosomes.