Research Paper Volume 12, Issue 5 pp 4111—4123

Long noncoding RNA LINC00461 induced osteoarthritis progression by inhibiting miR-30a-5p

Figure 1. TNF-α and IL-6 induced the expression of LINC00461 in chondrocytes. (A) Cell proliferation was determined by CCK-8 analysis. (B) TNF-α promoted chondrocyte growth, as demonstrated by CCK-8 analysis. (C) IL-6 enhanced the expression of LINC00461 in chondrocytes, as shown by qRT-PCR. GAPDH was used as the internal control. (D) TNF-α induced LINC00461 expression in chondrocytes. *p<0.05 and **p<0.01.