Research Paper Volume 12, Issue 5 pp 4111—4123

Long noncoding RNA LINC00461 induced osteoarthritis progression by inhibiting miR-30a-5p

Figure 5. Elevated expression of LINC00461 induced chondrocyte proliferation, cell cycle progression, inflammation, and extracellular matrix (ECM) degradation. (A) Overexpression of LINC00461 enhanced cell proliferation in chondrocytes. (B) Elevated expression of LINC00461 increased cell cycle progression in chondrocytes. (C) IL-6 expression was upregulated in chondrocytes after LINC00461 treatment. (D) LINC00461 overexpression enhanced IL-10 expression in chondrocytes. (E) Ectopic expression of LINC00461 promoted MMP-2 expression in chondrocytes. (F) The expression level of MMP-3 was increased in chondrocytes after LINC00461 treatment. (G) Elevated expression of LINC00461 enhanced MMP-13 expression. (H) The expression of type II collagen was measured by qRT-PCR assay. *p<0.05 and **p<0.01.