Research Paper Volume 12, Issue 4 pp 3791—3806

Baicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota

Figure 8. Baicalin decreases plasma clusterin levels and pro-inflammatory cytokines in the hippocampus of repeated cerebral ischemia-reperfusion model mice. (A) The plasma levels of clusterin, and (B) interleukin (IL)-1β, (C) IL-6, and (D) tumor necrosis factor α (TNFα) levels in the hippocampus of control, model, and baicalin-treated model group mice are shown. Note: *** denotes P<0.001 compared with the control mice using unpaired Student`s t-tests; # denotes P<0.05,## denotes P<0.01, and ### denotes P<0.001 compared with the model mice using one-way ANOVA followed by Dunnett`s post hoc test. All the values are expressed as means ± S.D. Each group had 15 mice (n=15).