Research Paper Volume 12, Issue 4 pp 3828—3847

Ancestral stress programs sex-specific biological aging trajectories and non-communicable disease risk

Figure 1. MPS modifies the emotional and sensorimotor phenotype across the lifespan. (AC) MPS increased anxiety-like behaviours in young and aged males, but not in females. (DF) MPS exacerbated the age-associated reduction in learned helplessness. (GI) MPS induced sex- and age-specific effects in fore- and hindlimb skilled limb use. (J) Females showed higher locomotor activity than males at all ages. Asterisks indicate significances: *p<0.05. “b” indicates MPS effect. All data are presented as mean ± SEM.