Research Paper Volume 12, Issue 4 pp 3828—3847

Ancestral stress programs sex-specific biological aging trajectories and non-communicable disease risk

Figure 2. MPS determines physiological health trajectories. Plasma corticosterone and blood glucose levels and body weight in male and female rats revealed an effect of MPS across the lifespan. (A, B) MPS induced sex- and age-specific modifications in the stress response as indicated by reduced plasma corticosterone levels in young and aged males (A), and middle-aged females (B). (C, D) MPS elevated non-fasting blood glucose levels especially in young females. (E, F) MPS diminished body weight in young and increased it in old males (E). Body weight in males and females increased with age, while males weighed twice as much as females. Asterisks indicate significances: *p<0.05, **p<0.01, ***p<0.001; “b” indicates MPS effect.