Research Paper Volume 12, Issue 4 pp 3828—3847

Ancestral stress programs sex-specific biological aging trajectories and non-communicable disease risk

Figure 5. MPS raises age-associated stress vulnerability via sex-specific miRNA and mRNA expression. Fold change of miRNA and mRNA expression as determined by deep sequencing of prefrontal cortex. (A) Expression of miR-34a, (B) miR-150 and miR-181a, (C) miR-124, (D) miR-29b indicate MPS-programming of aging trajectories. Biological processes and miRNA targets are shown for (E) miR-34a, (F) miR-150, (G) miR-124, and (H) miR-21. (I) Sex-specific changes in the expression of pre-B-cell leukemia transcription factor 3 (pbx3) and doublecortin (dcx) genes as a function of age. (J) Phenotype overview of pbx3 and dcx as per MDB database. All data are represented as log change relative to CONTROL levels. Blue, dashed line indicates age-specific CONTROL levels. Asterisks indicate significances: *p<0.05, **p<0.01. All data are presented as mean ± SEM, “b” indicates MPS effect, n=3 per age/sex/group.