Research Paper Volume 12, Issue 4 pp 3828—3847

Ancestral stress programs sex-specific biological aging trajectories and non-communicable disease risk

Figure 6. MPS defines cellular homeodynamics as reflected by deep learning metabolomics analysis. (A) Given their disease vulnerability, males revealed a characteristic metabolic signature in urine 1H-NMR spectra based on VIAVC testing. Individual metabolite changes are indicated; bars indicate % change from CONTROLS. (B) Pathway topology analysis showing all matched pathways according to p-values and pathway impact values in young males. This figure was created using the lists of metabolites identified in A. n=7 CONTROL and n=6 MPS rats; 1-MN 1-methylnicotinamide.