Research Paper Volume 12, Issue 5 pp 4163—4177

Reduced Ca2+ spark activity contributes to detrusor overactivity of rats with partial bladder outlet obstruction


Figure 2. Reduced properties of Ca2+ sparks in detrusor myocyte from DO model rats. (A, B) Confocal linescans of representative Ca2+ sparks in detrusor myocyte from unafflicted control (A) and DO afflicted (B) rats. (C) Summary data for Ca2+ spark related properties. Ca2+ spark frequencies decreased in detrusor myocytes of DO afflicted samples (a). Similarly, F/F0 (b), FWHM (c), rise time (d), and half-time decay (e) all were found to have been significantly reduced in DO afflicted myocytes. We used unpaired t tests for comparisons between treatment groups. VS control *P<0.05, **P<0.01.